Normoxic Challenges Utility to Evaluate Blood Loss

Normoxic Challenges Utility to Evaluate Blood Loss Through Cerebral Oxygenation

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03194581

Enrollment

Registered

2017-06-21

Start date

2017-10-01

Completion date

2018-09-30

Last updated

2022-03-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemorrhage

Brief summary

This study will evaluate the impact of repeated normoxic challenges on cerebral oxygenation as a measure of the effect of blood loss on DO2 during surgical procedures.

Interventions

DEVICECerebral oxygenation

Evaluate cerebral oxygenation using normoxic challenges

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Elective surgery * High risk of intraoperative blood loss * General anaesthesia

Exclusion criteria

* Respiratory insufficiency * Ischemic heart disease * Stroke * ASA classification \> 3 * Laparoscopic surgery

Design outcomes

Primary

Measure	Time frame
Change in cerebral regional oxygen saturation	Before and 3 minutes after normoxic challenges

Countries

Portugal

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026