Acute Kidney Injury, Chronic Kidney Diseases
Conditions
Brief summary
Acute kidney injury is a frequent and growing complication associated with a risk of progressing into a chronic kidney disease. Recent guidelines have recommended systematic consultations with a nephrologist 3-6 months following hospitalization. Risk factors of developing chronic kidney disease between hospital visits are understudied.
Interventions
OTHERmonitoring for progression to chronic kidney disease
Collect clinical information and assess risk factors
Sponsors
Centre Hospitalier Universitaire de Nīmes
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \>18 years * Suffering from acute kidney injury treated with dialysis * hospitalized in a university center from August 2016 to December 2017 with severe AKI defined according to 2 of the 3 criterion definitions of KDIGO stage AKI: an increase in SCr above 354 μmol/Lor renal replacement therapy (RRT) indication, but not the 3-fold increase in SCr increase within 7 days with SCr below 354 μmol/L. * The patient has been informed and does not oppose the study * The patient is insured or the beneficiary of a health insurance policy
Exclusion criteria
* The patients is under judicial protection or state guardianship * Patient has chronic kidney disease(CKD) KDIGO stage 5 * It proves impossible to give the patient clear information * patients living with kidney transplant * plan dialysis for bilateral surgery nephrectomy * patient refuse to participate and patients with no health insurance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Develop a prognostic score of progression to chronic kidney disease at 6 months in patients requiring hospitalization for dialysis for acute kidney injury to identify those who would benefit from consultation with a nephrologist | 6 months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Identify new risk factors for progression to chronic kidney disease at 6 months post dialysis for acute kidney injury pre-hospitalization and during hospitalization and day of discharge | 6 months | — |
| Identify renal phenotype of patients with chronic kidney disease | 6 months | characterization from renal biopsy |
| Evaluate mortality during hospital stay | 1 months | — |
| Evaluate mortality at medium-term | 6 months | — |
| Identify specific therapeutic interventions put into place during the 6 month consultation | 6 months | — |
Countries
France
Outcome results
None listed