Differentiated Thyroid Cancer
Conditions
Brief summary
Description of the role of a post-operative external beam radiotherapy in patients with differentiated thyroid cancer.
Detailed description
The role of post-operative external beam radiotherapy (EBRT) in differentiated thyroid cancer is still discussed considering the low clinical aggressiveness and the availability of ablative 131Iodine therapy. However, there is a subgroup of tumors which lose the ability to capture Iodine over time. This study wants to describe the role of a post-operative external beam radiotherapy in patients with differentiated thyroid cancer.
Interventions
None listed
Sponsors
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* detectable thyroglobulin (Tg), * negative post-metabolic radiotherapy whole body scintigraphy, * no surgical indications.
Exclusion criteria
* prior radiotherapy in the head and neck area * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Progression free survival (PFS) | 6 months | Progression-free survival (PFS) after radiotherapy is evaluated with CT-scan and 18F FDG PET-scan. Also laboratory tests are performed (HTG serum level evaluation in case of biochemical recurrence). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| toxicities | 6 months | Acute and late toxicities after radiotherapy are assessed with CTCAE v. 4.03 and EORTC-RTOG scales, respectively. |
Outcome results
None listed