Interaction Research on Cognitive Impairment and Emotional Disorder in End-stage Renal Disease

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03191409

Enrollment

Registered

2017-06-19

Start date

2017-06-15

Completion date

2019-06-30

Last updated

2017-07-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain Damage, End-stage Kidney Disease

Keywords

cognitive impairment, ESRD, functional MRI

Brief summary

End stage renal disease (ESRD) is the last stage (stage 5) of chronic kidney disease (CKD). Abnormalities of cognitive function and high levels of depression or anxiety incidence are characteristic of hemodialysis patients. In this research project, the investigators subject in ESRD patients starting hemodialysis as the carrier. Based on the longitudinal research design, using multimodal neuroimaging data，combining with the interact relationship between changes of brain morphology, the dysfunction of resting-state and-task state with cognitive impairment and abnormal emotions.Establish brain structure-function change model associated with dialysis progression, Explore imaging markers of central and disease development characteristics in ESRD patients. the investigators attempt to clarify the core mechanism of kidney-brain axis damage, thus provide evidence for early cognitive-behavioral therapy to CKD patient.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

1. Age 18-50 years; 2. ESRD patients who will start hemodialysis 3. High quality MRI scan; 4. dextromanual

Exclusion criteria

1. Diabetes,Brain tumor,brain trauma 2. Neuropsychiatric disease

Design outcomes

Primary

Measure	Time frame	Description
change in cognitive function	Change from Baseline to 3 Months after dialysis	Cognitive testing will be performed for assessment

Secondary

Measure	Time frame	Description
Change in brain MRI	Change from Baseline to 3 Months after dialysis	Brain MRI will be performed before dialysis initiation and dialysis more than 3 months

Countries

China

Contacts

Primary ContactMing Zhang, Ph.D

zmmri@163.com18991232265

Outcome results