Major Depressive Episode
Conditions
Brief summary
The study aimes at identifying whether positive expectations have an impact on the way depressive participants experience emotions in the form of sadness.
Interventions
OTHERPlacebo nasal spray
The placebo nasal spray consists of sesame oil and does not contain any active drug.
OTHERFilm sequence
All groups watch the film sequence that is supposed to induce sadness.
Sponsors
Philipps University Marburg
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* major depression (mild to moderate) * fluent in German language
Exclusion criteria
* bipolar disorder, psychotic disorder, substance dependence * cardiovascular disease, severe kidney or liver disease, epilepsy * change of psychotropic medication intake within the last four weeks * allergic to capsaicin * allergic to sesame oil * students in medicine, pharmacy, or psychology in their third year or older * completed studies in medicine, pharmacy or psychology
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sadness | Directly after watching the film sequence, no follow-up assessments | Items of PANAS-X |
Countries
Germany
Outcome results
None listed