Apathy, Impulsive Behavior, Motivation
Conditions
Brief summary
The purpose of this study is to evaluate the impact of methylphenidate, a mixed dopaminergic and noradrenergic agent, onto the different components of motivation: decision-making, effort allocation and instrumental learning.
Interventions
DRUGRitalin (methylphenidate)10Mg Tablet
oral ingestion of 3 tablets in a single-dose
DRUGPlacebo Oral Tablet
oral ingestion of 3 tablets in a single-dose
Sponsors
Institut National de la Santé Et de la Recherche Médicale, France
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* weight\>= 50kg and \<=90kg * free and informed consent * social security affiliation * no chronic illness * no previous participation to a protocol wth similar tasks * no special legal status (guardianship,trusteeship) * no personnal or familial neurologic or psychiatric background * no contraceptive device for a reproductive woman
Exclusion criteria
* inability to squeeze a handgrip * smoking * psychoactive substance consumption less than 3 weeks ago * pregnant or breastfeeding woman * hypersensitivity to methylphenidate * hyperthyroidism * cardiovascular or cerebrovascular disease * respiratory, hepatic or renal failure * glaucoma * pheochromocytoma * gluten intolerance or hypersensitivity * galactosemia, glucose malabsorption syndrome, lactase deficit * countraindicated meds (IMAO, IMAO-A, orhtosympathomimetics, alcaloids, linezolin, enzymatic inducers, psycho-active drugs)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| coefficient of sensitivity to reward | two hours after administration | Parameter characterizing the influence of reward expectation/experience onto behavior for each individual. This parameter is estimated through the fit of computational models to behaviors recorded in a battery of motivational tasks (choice task, effort task, Learning task). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| coefficient of sensitivity to effort | two hours after administration | Parameter characterizing the influence of effort expectation/experience onto behavior for each individual. This parameter is estimated through the fit of computational models to behaviors recorded in a battery of motivational tasks (choice task, effort task, Learning task). |
| coefficient of sensitivity to punishment | two hours after administration | Parameter characterizing the influence of punishment expectation/experience onto behavior for each individual. This parameter is estimated through the fit of computational models to behaviors recorded in a battery of motivational tasks (choice task, effort task, Learning task). |
| coefficient of sensitivity to delay | two hours after administration | Parameter characterizing the influence of delay expectation onto behavior for each individual. This parameter is estimated through the fit of computational models to behaviors recorded in a battery of motivational tasks (choice task, effort task, Learning task). |
Countries
France
Outcome results
None listed