Kidney Diseases
Conditions
Keywords
Renal reserve, physiological study, diagnostic testing
Brief summary
Single arm physiological study to measure renal functional reserve as a biomarker of kidney function and health
Detailed description
The investigators will measure glomerular filtration rate using urinary clearance of cold iothalamate before and after an oral protein load in patients with chronic kidney disease and healthy volunteers.
Interventions
DIETARY_SUPPLEMENTIngestion of protein
Oral protein load as a physiological stimulus to temporarily increase glomerular filtration rate
Sponsors
Brigham and Women's Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Intervention model description
Physiological study to measure the change in glomerular filtration rate after an oral protein load
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Age ≥18 2. Estimated GFR \>30 mL/min/1.73m2
Exclusion criteria
1. Allergy to iothalamate, shellfish or iodine 2. Use of metformin or amiodarone 3. Inability to maintain a stable regimen of medications which affect GFR for \> one week prior to participation (e.g. non-steroidal anti-inflammatory drugs, angiotensin converting enzyme inhibitors, angiotensin receptor blockers) 4. Use of medications which directly affect elimination of creatinine (e.g. cimetidine and trimethoprim) 5. Acute exacerbation of asthma or chronic obstructive pulmonary disease within 3 months requiring hospitalization or oral steroid therapy 6. Inadequate intravenous access 7. Severe anemia (Hct \<21%) 8. Acute kidney injury (rise in creatinine to ≥1.5 times the previous baseline or by ≥ 0.3 mg/dL on most recent labs prior to enrollment) 9. History of contrast-induced nephropathy 10. Hyperthyroidism 11. Pheochromocytoma 12. Sickle cell disease 13. Urinary retention or incontinence 14. Status post organ transplant 15. Pregnancy or active breast feeding 16. Cognitive impairment with inability to give consent 17. Institutionalized status
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in glomerular filtration rate after ingestion of protein | Single full-day clinic visit: Repeated glomerular filtration rate measurements are to be performed over the course of the day at a single study visit for each participant. | Short term-changes in the glomerular filtration rate will be measured before and after ingestion of oral protein |
Countries
United States
Outcome results
None listed