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Paravertebral Block for Pain Management After Appendectomy

Paravertebral Block for Postoperative Pain Management in Adult Patients Undergoing Appendectomy

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03189693
Enrollment
60
Registered
2017-06-16
Start date
2017-06-01
Completion date
2022-04-30
Last updated
2022-01-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Reduce Pain After Appendectomy

Brief summary

Paravertebral Block (PVB) was shown to be a successful and useful technique of anesthesia and analgesia. Its effect was evident in thoracic and abdominal surgeries. In the setting of appendectomy, somatic PVB has been used for pediatric patients. It was shown to decrease opioid consumption and provide prolonged pain relief. Hence, it would be beneficial to examine the analgesic effect of PVB on appendectomy in adult patients.

Detailed description

Patients undergoing appendectomy will be randomly allocated into two equal groups using the sealed envelope technique. All patients will receive general anesthesia (GA). Patients in group I will receive two PVB injections at levels T12-L1 and L1-L2 using anesthetic mixture, while patients in Group II will receive placebo. Paravertebral Block Technique Unilateral right side nerve stimulator-guided PVB is performed while patients are in the left lateral decubitis position. The appropriate levels for the PVB are determined by palpation of the spinous processes. An intervertebral line is drawn at the appropriate levels and the injection site is marked 2.5 cm lateral to the midline. After aseptic preparation of the skin, 1 mL 1% lidocaine is infiltrated at the injection sites. A 21-G nerve stimulation needle (Stimuplex; B. Braun, Melsungen, Germany) is advanced 1-2 cm perpendicularly to the skin using a nerve stimulating current of 2.5-5.0 mA, while closely watching for contractions of the abdominal muscles. The tip of the needle is adjusted to maintain muscle contractions while reducing the stimulating current to approximately 0.5-0.6 mA. 4 mL of the local anaesthetic mixture is injected at each injection site. Each 20 mL of the local anaesthetic mixture contains: 8mL lidocaine 2%, 8 mL lidocaine 2% with epinephrine 5µg/mL and 4 mL bupivacaine 0.5%.

Interventions

OTHERPVB

nerve stimulator-guided PVB will be performed at two levels

OTHERPlacebo

nerve stimulator-guided PVB containing placebo will be performed at two levels

OTHERGA

All patients will receive general anesthesia.

4 mL of the local anesthetic mixture is injected at each injection site. Each 20 mL of the local anaesthetic mixture contains: 8mL lidocaine 2%, 8 mL lidocaine 2% with epinephrine 5µg/mL and 4 mL bupivacaine 0.5%.

Sponsors

Makassed General Hospital
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Older than 18 years * Scheduled to undergo appendectomy

Exclusion criteria

* cardiac disease, * developmental delay, * neurologic deficit, * allergies to any of the drugs routinely used in anesthesia management.

Design outcomes

Primary

MeasureTime frameDescription
Analgesic consumption24 hours postoperativelyThe quantity of analgesics consumed will be recorded

Secondary

MeasureTime frameDescription
hemodynamic stability measured through mean arterial pressure (MAP).Approximately 1 hourIntraoperative hemodynamic stability measured through mean arterial pressure (MAP)

Countries

Lebanon

Contacts

Primary ContactZoher Naja, MD
zouhnaja@yahoo.com+9611636000

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026