Burns, Cicatrization, Coagulation Disorder, Endothelial Dysfunction, Factor XIII Deficiency
Conditions
Keywords
Burns, Coagulation, Factor XIII, Glycocalix, Cicatrization
Brief summary
Prospective observational study in which FXIII levels and coagulation tests and cicatrization are measured during the 30 days after the thermal trauma.
Detailed description
This is a prospective observational pilot study in which the levels of FXIII and coagulation, anticoagulation, fibrinolysis, endothelial tissue damage and cicatrization are at the arrival of the patient to hospital, 24 hours before the first surgical intervention, 24h After the first surgical intervention, at 7 days after the first intervention and at 30 days after the thermal trauma, in this moment the healing will also be evaluated. All burn patients who meet the proposed inclusion criteria will be included and entered into the Burn Unit of the Vall d'Hebron University Hospital from the start of the study until reaching a minimum of 20 cases or a temporary term of 2 years.
Interventions
DIAGNOSTIC_TESTCoagulation tests
The following plasma values will be measured: prothrombin time, activated partial thromboplastin time, thrombin time, functional fibrinogen, lactate, base excess, fibrin monomers, Factor XIII, Factor XII, Factor VIII, Fact von Willebrand, Plasmin, Plasminogen, Alpha-2-antiplasmin, antithrombin, protein C, Heparan sulfate, synecan 1. Surveys on the state of healing and moisture titration will be performed using Tewamether
Sponsors
Hospital Universitari Vall d'Hebron Research Institute
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Burned patients with a burned body surface of 20% or more * Over 18 years of age
Exclusion criteria
* ABSI (Abbreviated Burns Severity Index) greater than or equal to 12 * Associated polytrauma * Coagulation deficit previously known * Treatment with anticoagulants * Electrocution burns * Admission into the unit after hour 6 after thermal trauma * The refusal of the patient, familiar or responsible to participate in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Factor XIII | 30 days | Blood Coagulation Factor XIII levels |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Activated Partial Thromboplastin Time (APTT) | 30 days | Activated Partial Thromboplastin Time blood levels |
| Thrombin Time (TT) | 30 days | Thrombin Time blood levels |
| Fibrinogen | 30 days | Functional fibrinogen blood levels |
| Lactate | 30 days | Lactate blood levels |
| Base Excess (BE) | 30 days | Base Excess blood levels |
| Fibrin monomers | 30 days | Fibrin monomers blood levels |
| Factor XII | 30 days | Factor XII blood levels |
| Factor VIII | 30 days | Factor VIII blood levels |
| Factor von Willebrand | 30 days | Factor von Willebrand blood levels |
| Plasmin | 30 days | Plasmin blood levels |
| Plasminogen | 30 days | Plasminogen blood levels |
| Prothrombin Time (PT) | 30 days | Prothrombin Time blood levels |
| Antithrombin (AT) | 30 days | Antithrombin blood levels |
| Protein C | 30 days | Protein C blood levels |
| Heparan sulfate | 30 days | Heparan sulfate blood levels |
| Syndecan 1 | 30 days | Syndecan 1 blood levels |
| Healing Vancouver test | 30 days | The Vancouver survey will be conducted on the state of healing |
| Healing POSAS test | 30 days | The POSAS survey will be conducted on the state of healing |
| Tewamether moisture titration | 30 days | Tewamether consists of two pairs of sensors to measure the humidity and temperature gradients in two different spacings |
| Surgical bleeding survey | 10 days | A surgical team survey will be performed on intraoperative bleeding (during the first debridal surgery) |
| Reintervention due to bleeding | 11 days | The need of reintervention because of bleeding within the next 24 hours after the first debridal surgery will be registered |
| Surface debrided | 10 days | The percentage of debrided surface and type of debridement (in the first debriding surgery) |
| Surgery Bleeding | 15 days | Estimated bleeding according to the modified Gross formula (in the first debriding surgery) |
| Alpha-2-antiplasmin | 30 days | Alpha-2-antiplasmin blood levels |
Contacts
Primary ContactPatricia Guilabert, MD
Outcome results
None listed