Low Birth Weight Infants
Conditions
Keywords
Alkaline Phosphatase, Pregnancy, Suboptimal fetal growth, Placental insufficiency, Low birth weight, IUGR
Brief summary
Alkaline phosphatase is known to be produced by syncytiotrophoblasts in the placenta and its levels are normally increased in pregnancy. Therefore, it would be reasonable to hypothesize that alkaline phosphatase would be low to low normal in cases of low birth weight / intrauterine growth restriction (IUGR)/ placental insufficiency.
Detailed description
The purpose of this study will be to determine if alkaline phosphatase can be used as a predictor for suboptimal fetal growth, placental insufficiency and low birth weight (birth weight less than 2500 grams). It will also help determine if alkaline phosphatase can be used as a screening tool for low birth weight/IUGR at the time of the 24 to 28 week labs.
Interventions
DIAGNOSTIC_TESTTesting of Alkaline Phosphatase Levels
Testing of alkaline phosphatase levels at the time of the 24w0d to 28w6d week labs.
Sponsors
TriHealth Inc.
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
• Patients enrolled between 24w0d and 28w6d weeks gestational age will be included. The blood specimen of the patients enrolled will be held until delivery.
Exclusion criteria
* Multiple gestations * Known congenital malformations (any, except Pyelectasis) * Chronic hypertension * Inflammatory bowel disease (IBD) * Gall bladder disease * Active bone disease (ie, skeletal dysplasia, healing fracture) * Active liver disease (ie, hepatitis, cholestasis, cholelithiasis (gallstones)) * Pre-existing type 1 and 2 Diabetes * Early-onset IUGR
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Birth Weight at Delivery | At Delivery | Birth Weight at Delivery |
Countries
United States
Outcome results
None listed