The Preventive Effects of Sub Hypnotic Dose of Propofol for Nausea and Vomiting Induced by Hemabate

The Preventive Effect of Sub Hypnotic Dose of Propofol for Nausea and Vomiting Induced by Hemabate

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03185156

Enrollment

Registered

2017-06-14

Start date

2017-06-28

Completion date

2018-01-30

Last updated

2018-10-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nausea and Vomiting

Keywords

nausea and vomiting, hemabate, propofol

Brief summary

This is a randomized, placebo-controlled trail, the objective of this study is observation the effect of sub hypnotic dose of propofol for prevention of nausea and vomiting induced by hemabate during spinal anesthesia for elective cesarean section. The primary outcome is the presence of post-delivery intra-operative nausea and vomiting in parturients. The patients demographic characteristics, blood pressure, sensory block level, and the medications will be collected.

Interventions

DRUGPropofol

first dose 0.3mg/Kg propofol, then 1mg/Kg/hr micro-pump

DRUGNormal saline

first dose 0.03ml/Kg placebo saline, then 0.1ml/Kg/hr micro-pump

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Intervention model description

60 maternal aged 20-40 years will be collected

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 40 Years

Healthy volunteers

Inclusion criteria

* Patients aged 20-40 years; * American Standards Association status I-II.

Exclusion criteria

* Patients with allergy or hypersensitivity to propofol, lipid emulsion, or granisetron; * History of nausea or vomiting within 24h before cesarean delivery; * History of gastrointestinal or psychiatric disease, motion sickness, smoking, postoperative nausea and vomiting; * Morbid obesity; * Consumption of drugs such as opioids, antiemetics , H2 antagonists, phenothiazines and/or corticosteroids within 24h before the study period; * Any chronic medical or surgical disorders complicating the pregnancy; * Conditions contraindicating regional anesthesia.

Design outcomes

Primary

Measure	Time frame	Description
The presence of nausea and vomiting	24 hours	the patients were not asked directly about nausea during the course of the surgery, but its incidence was recorded when spontaneously reported vomiting was recorded as observed by investigator

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 15, 2026