COPD, Pulmonary Vascular Disorder, Right Ventricular Dysfunction
Conditions
Brief summary
The pulmonary vasculopathy and right heart dysfunction in COPD are drawing increasing attention these days. Recent researches show that pulmonary vasculopathy and right heart dysfunction relate to greater severity in COPD. Applying appropriate modalities for early detection of pulmonary vasculopathy and right heart dysfunction is of great importance. What's more, the interaction mechanism between pulmonary vasculature, right heart and COPD still needs to be further studied. The aim of our study is to develop an assessment system of pulmonary vasculopathy and right heart dysfunction in COPD patients and elucidate their impact on COPD course and outcome.
Interventions
None listed
Sponsors
Chinese Academy of Medical Sciences, Fuwai Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* stable COPD patients
Exclusion criteria
* patents with other respiratory diseases and pulmonary hypertension other than group 3 PH; * psychopath, addict or patients not able to coordinate; * patients in pregnancy or breastfeeding; * patients with limited life expectancy; * patients with contraindiction for MRI or PET; * patients having cerebrovascular events in 3 months; * unstable COPD patients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| All-cause mortality | 3 years | survival rate in % |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| COPD exacerbations | 3 year | total times |
| GOLD degree | 3 year | Ⅰ-Ⅳ according to the pulmonary function |
| NYHA degree | 3 year | Ⅰ-Ⅳ according to the symptom |
Countries
China
Contacts
Primary ContactJianguo He He, MD
Outcome results
None listed