COPD, Non-invasive Positive Pressure Ventilation, Sleep Apnea Syndromes
Conditions
Brief summary
Chronic obstructive pulmonary diseases (COPD) coexisting with obstructive sleep apnea is called overlap syndrome (OS). Patients with OS seem to have worse prognosis than patients with only one disorder. Noninvasive positive pressure ventilation is an efficient treatment in obstructive sleep apnea, but the effectiveness in improving outcomes of OS patients is still not fully investigated. The aim of this non-randomized concurrent control trial is to evaluate noninvasive positive pressure ventilation's effectiveness in OS patients.
Interventions
DEVICENIPPV
BiPAP treatment for 3 years
Sponsors
Chinese Academy of Medical Sciences, Fuwai Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
non-invasive positive pressure ventilation
Eligibility
Sex/Gender
ALL
Age
40 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* patients with COPD and sleep apnea dyspnea syndrome
Exclusion criteria
* patients with non-stable hemodynamics; * patients with limited life expectancy; * patients with other severe respiratory diseases; * patients with motor neuron diseases; * patients with contraindications for NIPPV
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| COPD acute exacerbations | 3 years | total times of COPD acute exacerbations |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| COPD assessment test (CAT) score | 3 years | symptom score of COPD |
| modified British medical research council (mMRC) score | 3 years | dyspnea score |
| all-cause mortality | 3 years | survival rate in % |
Countries
China
Contacts
Primary ContactKe Hu, MD
Outcome results
None listed