Autistic Disorder
Conditions
Brief summary
Observe effects of oxytocin on individuals with autism spectrum disorder
Detailed description
To observe the effects of oxytocin on individuals with autism spectrum disorder according to gender, in facial recognition and eye tracking tests. The investigators will apply the nepsy and eye tracking tests before and 45 minutes after the puff with oxytocin or placebo at the dose of 0.4 IU / kg / dose maximum of 24 IU. The next week the volunteer will return and will do the same procedure because whoever took the placebo would take oxytocin and vice versa. Is a randomized, double-blind, placebo-controlled clinical trial.
Interventions
DRUGOxytocin
Single dose oxytocin 45 minutes before the test
OTHERplacebo
saline solution 0,9% spray nasal
Sponsors
University of Sao Paulo General Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
3 Years to 16 Years
Healthy volunteers
Yes
Inclusion criteria
Diagnosis of ASD by DSMV * CARS\> 30 * age between 3 and 16 years * stable (3 months with medication maintained or without medication)
Exclusion criteria
- pregnant women, infants and * participation in another research project of pharmacological or behavioral intervention in progress * Use of pituitary hormones, cortisol, androgens and estrogens. * heart problems: recent AMI, heart failure. * respiratory problems: pneumonia, respiratory failure, decompensated asthma, acute bronchitis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Eye tracking | on average of 1 year | Eye tracking program |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Nepsy | on average of 1 year | face recognize |
Countries
Brazil
Outcome results
None listed