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Long-term Follow-up of Anterior Cruciate Ligament Injury

Long-term Follow-up of Anterior Cruciate Ligament Injury

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03182647
Acronym
ACLLTFU
Enrollment
300
Registered
2017-06-09
Start date
2017-06-09
Completion date
2018-06-30
Last updated
2017-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anterior Cruciate Ligament Injury

Brief summary

Anterior cruciate ligament (ACL) rupture is one of the most common sports-related knee injuries. Because it is such a significant injury - requiring a long period of rehabilitation before the injured person is ready to return to physical activity, the burden of injury is high. This can help to explain why so much of orthopaedic research is devoted to evaluating the outcomes of ACL injury. However, while there has been extensive study of short-term (up to 5 years after injury) outcomes, few studies have followed patients beyond 15 years after their ACL injury. This is important because long-term follow-up can provide key insights to guide the information provided to newly injured patients (e.g. to help set realistic expectations of what the injured person can expect of their knee function in the future), and help us evaluate the efficacy of previous treatments. The primary aim is to assess the influence of an acute ACL injury on knee function and quality of life, 32-37 years after the index injury. Approximately 300 patients injured between 1980 and 1985 will be invited to participate in the study. Patient- and clinician-reported outcomes, and radiographic osteoarthritis will be evaluated.

Detailed description

Patients injuring their ACL between 1980 and 1985 have periodically been followed since the injury. Now, we plan to contact all patients and invite them to participate. The patients will be asked to 1. complete a questionnaire battery 2. visit the movement laboratory at Linköping University for an objective assessment of knee function and 3. have an x-ray of both knee joints. Baseline information including associated injuries, treatment and activity level exist for all the patients. At that time, rehabilitation was normally completed after 4-6 months for non-operatively treated patients, and nine months after ACL surgery.

Interventions

PROCEDURESurgically treatment of the ACL

Surgical initial ACL treatment

OTHERNon surgical initial ACL treatment

Non surgical initial ACL treatment

Sponsors

Linkoeping University
Lead SponsorOTHER_GOV

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
47 Years to 77 Years
Healthy volunteers
No

Inclusion criteria

* primary ACL injury between 1980 and 1985, age between 15 and 40 at injury

Exclusion criteria

* all patients from the initial cohort will be invited for participation

Design outcomes

Primary

MeasureTime frameDescription
Osteoarthritis32-37 years after ACL injuryDevelopment of osteoarthritis examined with tibiofemoral and patellofemoral radiographs
Self reported knee function32-37 years after ACL injuryKnee Injury and Osteoarthritis Outcome Score, KOOS 4 (Pain, Symptoms, Sport/Rec, QOL subscales)

Secondary

MeasureTime frameDescription
Quality of life32-37 years after ACL injuryACL-Quality of Life scale (ACL-QoL)
Physical activity32-37 years after ACL injuryTotal time over the previous week spent doing moderate, and vigorous activity AND accelerometer measures
Objective assessment of knee function32-37 years after ACL injuryConcentric isokinetic muscle strength
Associated injuries and additional surgery32-37 years after ACL injuryPatient reported

Countries

Sweden

Contacts

Primary ContactJoanna Kvist, Professor
joanna.kvist@liu.se+4613284664

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 17, 2026