IRM Cognition in Patients With Head Trauma

Longitudinal Descriptive Study of the Correlation Between Cognitive Functions, White Matter Anatomical Pathways and Functional Magnetic Resonance Imaging Activations in Patients With Moderate to Severe Head Trauma.

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03181373

Enrollment

Registered

2017-06-08

Start date

2014-09-26

Completion date

2018-12-31

Last updated

2017-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain-damaged Patients

Keywords

Craniocerebral injury, Mild and severe brain traumatic injury, Neuropsychological abilities, Clinical assessment, Anatomical and functional imaging

Brief summary

Longitudinal descriptive study of a cohort of twenty brain-damaged patients for a two years period.

Detailed description

The following data are collected in 3 months, 12 months then 24 months after the accident with followed data collection : * Clinical, neuropsychological assessments * Diffusion magnetic resonance imaging (MRI) for the reconstruction of anatomical pathways * Functional imaging data.

Interventions

OTHERCognitive rehabilitation program

Rehabilitation

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Adult patients, over the age of 18. * Mild traumatic brain injury (Initial Glasgow score between 9 and 12) * Severe brain injury (Initial Glasgow score between 3 and 8), * Diffuse axonal injury and/or focal lesions.

Exclusion criteria

* Patients with MRI contraindications, * Antecedents of brain lesions, * Important lesions of the lobes and cortex on cerebral CT, * Anoxic lesions related to cardiorespiratory arrest, * Must be able to perform neuropsychological tests, * Visual and auditory impairments. * Aphasia

Design outcomes

Primary

Measure	Time frame	Description
Changes in Baseline standardized volume of the white matter fascicles	at 3, 12 and 24 months	determined on the iplan software. Baseline measured at 3 months after brain traumatic injury.

Secondary

Measure	Time frame	Description
Measure of the volume of activations clusters	at 3, 12 and 24 months	during functional MRI for attention, motor, working memory, language tasks.
Location of activation clusters	at 3, 12 and 24 months	during functional MRI for attention, motor, working memory, language tasks.

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026