Health, Fitness, and Quality of Life in Adolescent Girls With Turner Syndrome

Pilot Study of Health, Fitness, and Quality of Life in Adolescent Girls With Turner Syndrome

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03181230

Enrollment

Registered

2017-06-08

Start date

2017-05-26

Completion date

2018-12-31

Last updated

2021-05-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Turner Syndrome, Turner Syndrome Karyotype 46,X With Abnormal Sex Chromosome , Except I(Xq), Turner Syndrome Mosaicism, 45, X/46, XX or XY, Turner Syndrome Mosaicism 46,X,I(X)(Q10)/45,X

Keywords

Turner syndrome, 45,XO, body composition, cardiometabolism, quality of life, fitness

Brief summary

This study plans to learn more about how the energy system works in girls with Turner syndrome. This is important to know so that the investigators understand how Turner syndrome relates to diseases such as diabetes, extra weight gain, heart disease and liver disease, and how this impacts day to day life.

Interventions

OTHERNo intervention

No intervention

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

FEMALE

Age

12 Years to 21 Years

Healthy volunteers

Inclusion criteria

* Female * Age 12-21 years * 45,XO karyotype in \>50% of cells tested with a diagnosis of Turner syndrome (TS) * Tanner stage 2-5 for breast development

Exclusion criteria

* Growth hormone treatment within the past 3 months * Diagnosis of type 1 or type 2 diabetes * Untreated hypertension with blood pressure \> 99%ile for sex, age and height or \>140/90 * Weight \> 300 lbs * Height \< 54 * Aortic sinus of Valsalva or ascending aorta z-score \> 2 * Other cognitive, psychiatric, or physical impairment resulting in inability to tolerate the study procedures, including vigorous exercise * Pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Peak oxygen consumption	Baseline	Peak oxygen consumption (VO2 peak) with a standard graded exercise (bicycle) test

Secondary

Measure	Time frame	Description
Quality of Life Survey	Baseline	Self and parent reported quality of life
Percent body fat	Baseline	Body composition by dual-energy x-ray absorptiometry
Insulin resistance (IR)	Baseline	Fasting insulin and glucose used to calculate homeostatic model assessment (HOMA)

Other

Measure	Time frame	Description
Qualitative structured interview	Baseline	Attitudes surrounding physical activity participation

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026