Childhood Cancer, Fertility Disorders
Conditions
Brief summary
Background: Due to the remarkable improvement in treatments these last decades, long term survival can be expected in more than 80% of childhood cancer patients. Unfortunately, cancer treatments can be harmful to the gonads and can affect reproductive and endocrine functions. While loss of fertility is a major concern for most patients, sperm cryopreservation should be offered to all pubertal male patients. For prepubertal boys, only the experimental option of testicular biopsy in order to cryopreserve testicular stem cells can be proposed. Primary aims \- To cryopreserve testicular tissue of prepubertal patient receiving highly gonadotoxic oncological treatment. Secondary aims * To cryopreserve testicular tissue after failure of sperm cryopreservation in pubertal patient with high risk of infertility * To create a database in order to record clinical and biological follow-up data * To create a research biobank for future research projects Multicentric study: HUG, CHUV, UKBB
Interventions
PROCEDUREtesticular tissue biopsy
testicular tissue biopsy during general anesthesia
Sponsors
Gumy-Pause Fabienne
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
3 Months to 18 Years
Healthy volunteers
No
Inclusion criteria
* Prepubertal patients aged 3 months and older * Peri and pubertal patients after failure of sperm cryopreservation * Patients presenting high risk of infertility because of gonadotoxic treatments (i.e high dose of alkylating agents, testicular irradiation, total body irradiation). * Multidisciplinary team consensus in favour of proposition to cryopreserve testicular tissue
Exclusion criteria
* Patients under the age of 3 months * Refusal of the patient and/or his parents * Treatments that are not highly gonadotoxic
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of pediatric cancer patient who will undergo testicular tissue cryopreservation for fertility preservation | 0-20 years |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of complications related to the testicular biopsy (safety) | 0-20 years | The safety will be assessed by recording the number of complications of the procedure (e.g. bleeding, infection, testicular atrophy) |
| Comparison of biochemical markers | 0-20 years | Comparison of biochemical markers (e.g., FSH; LH, AMH; Inhibin B, SHBG and testosterone) between patients who undergo testicular biopsy and controls |
Countries
Switzerland
Contacts
CONTACTFabienne Gumy-Pause, Dr
STUDY_CHAIRFabienne Gumy-Pause
University Hospital, Geneva
Outcome results
None listed