Childhood Cancer, Fertility Disorders
Conditions
Brief summary
Background: Due to the remarkable improvement in treatments these last decades, long term survival can be expected in more than 80% of childhood cancer patients. Unfortunately, cancer treatments can be harmful to the gonads and can affect reproductive and endocrine functions. While loss of fertility is a major concern for most patients, only the experimental option of ovarian tissue cryopreservation can be proposed to prepubertal girls with a high risk of infertility. For pubertal patient, cryopreservation of mature oocytes after ovarian stimulation can be offered if oncological treatment debut can be delayed. As it is often not possible, ovarian tissue cryopreservation can also be offered. Primary aims \- To cryopreserve ovarian tissue of pre or peripubertal patient who will be receiving highly gonadotoxic oncological treatment. Secondary aims * To create a database in order to record clinical and biological follow-up data * To pool resources with Fertisave Registry * To create a research biobank for future research projects Multicentric study: HUG, CHUV
Interventions
PROCEDUREovarian tissue biopsy
ovarian tissue biopsy during general anesthesia
Sponsors
Gumy-Pause Fabienne
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
2 Months to 18 Years
Healthy volunteers
No
Inclusion criteria
* Pediatric pre ou peripubertal patient aged 2 months and older * Patient presenting high risk of infertility because of gonadotoxic treatments (i.e. high dose of alkylating agents, ovarian irradiation, total body irradiation) * Multidisciplinary team consensus in favour to proposition to cryopreserve ovarian tissue.
Exclusion criteria
* Patient under the age of 2 months * Refusal of the patient and/or her parents * Treatments that are not highly gonadotoxic
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of pediatric cancer patient who will undergo ovarian tissue cryopreservation for fertility preservation | 0-20 years |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of complications related to the ovarian biopsy (safety) | 0-20 years | The safety will be assessed by recording the number of complications of the procedure (e.g. bleeding, infection) |
| Comparison of biochemical markers | 0-20 years | Comparison of biochemical markers (e.g., FSH; LH, AMH, progesterone, oestradiol) between patients who undergo ovarian biopsy and controls |
Countries
Switzerland
Contacts
STUDY_CHAIRFabienne Gumy-Pause, Dr
University Hospital, Geneva
Outcome results
None listed