Post - Adolescence Acne
Conditions
Keywords
Post - adolescence acne, Topical 2% ketoconazole cream
Brief summary
To study efficacy (total numbers of acne reduction) and safety of 2% Ketoconazole cream in Thai females with Mild degree Post-Adolescence acne comparing with placebo for a period of 12 weeks.
Interventions
DRUG2% ketoconazole cream
2% ketoconazole cream applies twice daily
DRUGHydrophilic Cream
Hydrophilic cream (in-house preparation) applies twice daily
Sponsors
Chulalongkorn University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
25 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* regular menstrual cycle with mild degree of post - adolescence acne * agree to stop topical and systemic medication for acne treatment for 2 and 4 weeks respectively.
Exclusion criteria
* Pregnancy or lactation * Other active rashes on faces. * Allergic to ketoconazole or other ingredients of preparation. * Signs of hyperandrogenism * Taking anti-androgenic medications.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total numbers of acne reduction | 10 weeks | the difference of acne count (total numbers of acne before treatment - total numbers of acne after treatment) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Proportion of patients who achieve clear or almost clear after treatment | 10 weeks | clear or almost clear scored by Adult Female Acne Scoring Tool |
Countries
Thailand
Outcome results
None listed