Cholangiocarcinoma, Hepatocellular Carcinoma, Liver Carcinoma, Surgery
Conditions
Brief summary
Combined hepatocellular and mass-forming cholangiocarcinoma (cHCC-MFCCC) is a rare tumor. The aim of this study was the analysis of the outcome comparing such tumor with classic hepatocellular carcinoma (HCC) and mass-forming cholangiocarcinoma (MFCCC).
Detailed description
The institutional prospectively maintained database was queried, and 20 patients with cHCC-MFCCC were identified. A 2:1 match was performed with 40 patients operated in the same period for HCC, and with 40 operated for MFCCC. Only T1 or T2 patients N0 M0 were considered. Primary endpoint was the overall survival (OS) and disease-free survival (DFS).
Interventions
PROCEDUREHepatectomy
Removal of a part of the liver
Sponsors
University of Milan
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* positive histology for cHCC-MFCCC, HCC, and MFCCC * complete clinical, surgical, pathological and follow-up data.
Exclusion criteria
* patients preoperatively treated with chemotherapy, radiofrequency ablation or trans-arterial therapies were excluded. * patients operated for recurrent disease and/or with non-radical surgery * patients with missing data were also excluded
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Survival analysis | From 3 months after surgery up to 60 months after surgery | Analysis of overall and disease-free survival of patients resected for cHCC-MFCCC versus those resected for HCC versus those resected for MFCCC |
Outcome results
None listed