Diastolic Dysfunction, Hypertension, Inflammation
Conditions
Keywords
Diastolic Dysfunction, Hypertension, HMGB1
Brief summary
This study evaluated the association between HMGB1 and diastolic dysfunction in hypertensive patients. HMGB1 level were tested in all patients, and diastolic function determined by echocardiographic.
Interventions
None listed
Sponsors
Jing Li
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
All of the hypertensive patients in both diastolic dysfunction and control groups were either newly diagnosed or were aware of hypertension without using any pharmacotherapy. \-
Exclusion criteria
Individuals already under treatment for hypertension were not include. \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Differences of HMGB1 levels between hypertensive patients with and without diastolic dysfunction | on the day of admission | Blood samples of all individuals are collected on the day of admission and HMGB1 levels are tested. Echocardiographic assessment is performed with echocardiography device by using 2.5-3.5 Mega Hertz(MHz) transducer in the lateral decubitis position. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Differences of HMGB1 levels between grades of diastolic dysfunction | on the day of admission | Blood samples of all individuals are collected on the day of admission and HMGB1 levels are tested. Echocardiographic assessment is performed with echocardiography device by using 2.5-3.5 Mega Hertz(MHz) transducer in the lateral decubitis position. |
Outcome results
None listed