Polymyxin B Hemoperfusion, Septic Shock
Conditions
Brief summary
Polymyxin B hemoperfusion (PMX-HP) is mainly used to remove endotoxins in septic shock patients with intra-abdominal infections. Because of the concerns of postoperative bleeding, physicians may hesitate to use anticoagulation in patients with septic shock within a few hours after an abdominal operation. We developed a heparin dosing score protocol for heparin dosage adjustment. The purpose of the study is to examine the safety and efficacy of the heparin dosing score protocol.
Interventions
None listed
Sponsors
National Taiwan University Hospital
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* intra-abdominal septic shock patients or documented Gram-negative bacterial septic shock patients who received polymyxin-B hemoperfusion in National Taiwan University Hospital during October 2013-December 2016
Exclusion criteria
* pregnant woman * patients with do-not-resuscitate declaration * uncontrolled bleeding within 24hr
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| premature cartridge clotting rate | 2 hours | the incidence of premature cartridge clotting within 2hr |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| bleeding event rate | 24 hours | the incidence of substantial bleeding event within 24hr |
Countries
Taiwan
Contacts
Primary ContactChen-Tse Lee, MD
Outcome results
None listed