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Assessment of Dried Blood Spot Thyroglobulin and Urinary Iodine Concentration in Pregnant Women

Assessment of Dried Blood Spot Thyroglobulin in Pregnant Women to Redefine the Range of Median Urinary Iodine Concentration That Indicates Adequate Iodine Intake

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03176706
Acronym
STRIPE
Enrollment
2900
Registered
2017-06-05
Start date
2017-08-09
Completion date
2019-08-31
Last updated
2020-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Iodine Deficiency, Pregnancy Related

Brief summary

To avoid iodine deficiency and its consequences in pregnant women and their offspring, women should reach a sufficient iodine intake long before conception. To monitor iodine status, median urinary iodine concentration (UIC) is widely used in pregnant women (PW). Thyroglobulin (Tg) us another marker used to assess iodine status . In this study, urine samples as well as dried blood spots will be collected to measure UIC and Tg (as well as other hormones to define thyroid function) in PW. The results shall be used to reassess the threshold which defines iodine status in PW according to UIC.

Interventions

OTHERno intervention

this is a completely observational study, NO INTERVENTION

Sponsors

Swiss Federal Institute of Technology
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 44 Years
Healthy volunteers
Yes

Inclusion criteria

1. Generally healthy 2. No major medical illness, no thyroid disease, and taking no chronic medication 3. No use of iodine containing dietary supplements 4. No use of iodine-containing X-ray /CT contrast agent or iodine containing medication within the last year 5. Aged between 18 and 44 at enrollment 6. Singleton pregnancy 7. Non-smoking 8. Residence at study site since 12 months or longer

Design outcomes

Primary

MeasureTime frameDescription
Urinary iodine concentration and Thyroglobulin concentration in pregnant women.June 2018Analysis of urine and blood samples to find urinary iodine concentration and Thyroglobulin concentration of each participant.

Countries

New Zealand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026