Major Adverse Cardiovascular Events, Percutaneous Coronary Intervention, Saphenous Vein Graft Disease, Virtual Histology Intravascular Ultrasound
Conditions
Brief summary
The study is a prospective cohort study conducted in Tianjin Chest Hospital, China. Patients with saphenous vein graft disease after coronary artery bypass graft, and planning for receiving percutaneous coronary intervention after virtual histology intravascular ultrasound will be enrolled between May 2017 and April 2019. These subjects will be followed up at 1, 6 and 12 months post-operation of PCI to assess the short-term and long-term effect.
Interventions
DIAGNOSTIC_TESTvirtual histology intravascular ultrasound
Patients with saphenous vein graft disease will be examined using virtual histology intravascular ultrasound, and treated with percutaneous coronary intervention. Then they will be followed up at 1, 6 and 12 months.
Sponsors
Tianjin Chest Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients with SVGD after CABG * Planning to receive PCI using drug-eluting stents * 18 to 80 years old * Finishing VH-IVUS examination * Willing to participate in the study and sign informed consent
Exclusion criteria
* Patients with liver disfunction and renal failure * Aspirin and clopidogrel allergy * Acute myocardial infarction after CABG * History of stroke in the past 3 months * Gastrointestinal bleeding and hemoptysis recently * Vasculitis and non-atherosclerotic coronary artery disease * Coagulation disorders * History of malignancy * Women during pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of major adverse cardiovascular events | after PCI for saphenous vein graft disease (SVGD) in one year | Cardiac death, myocardial infarction, target lesion revascularization and target vessel revascularization are all major adverse cardiovascular events |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Thrombolysis In Myocardial Infarction (TIMI) flow in 24 hours after PCI for the SVGD | 24 hours after PCI for the SVGD | — |
| Number of slow reflow, no reflow or distal embolization of the saphenous vein graft after PCI on the basis of Corrected TIMI Frame Count (TFC) | 24 hours after PCI for the SVGD | — |
| Success rate of PCI | 24 hours after PCI for the SVGD | The residual stenosis of SVG is less than 50% and achieving TIMI flow 3 |
Countries
China
Contacts
Primary ContactXiang Li, Ph.D.
Outcome results
None listed