Depression, Treatment Resistant Depression
Conditions
Keywords
depression, trd, treatment-resistant depression, TMS
Brief summary
This study is aimed to help us learn about the effects of Transcranial Magnetic Stimulation at the forehead versus the left side of the head for treatment of Treatment Resistant Depression.
Detailed description
While transcranial magnetic stimulation (TMS) to the left dorsolateral prefrontal cortex (DLPFC) is an FDA approved treatment for depression, a growing and converging database suggests the medial prefrontal cortex (MPFC) may be even more critical to the neurobiology of depression and antidepressant treatment response. This study will compare the efficacy of high frequency transcranial madntic stimulation on these two sections of the brain.
Interventions
DEVICETMS
Transcranial magnetic stimulation (TMS) is a noninvasive procedure that uses magnetic fields to stimulate nerve cells in the brain to improve symptoms of depression.
Sponsors
White River Junction Veterans Affairs Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
21 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* 21-70 years old * inadequate response to one current antidepressant medication * currently depressed
Exclusion criteria
* psychiatric comorbidities
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Depressive symptoms measured by the 17-item Hamilton Depression Rating Scale | Change from baseline Hamilton-17 score to follow-up visit at 1 week after final TMS intervention. | Depressive symptoms will be measured by the 17-item Hamilton Depression Rating Scale. |
Countries
United States
Outcome results
None listed