Pulmonary Complication, Thoracic Surgery, Inflammation
Conditions
Brief summary
The investigator will evaluate the influence of lung protective ventilation on postoperative clinical outcome in patients undergoing one-lung ventilation for pulmonary lobectomy.
Detailed description
The hypothesis is that application of low tidal volume, moderate inspired oxygen fraction (FiO2) ,intermittent alveolar recruitment and positive end-expiratory pressure (PEEP) would be more beneficial than conventional ventilation in patients.
Interventions
PROCEDUREConvential Ventilation 1
High tidal volume, moderate inspired oygen fraction (FiO2).
PROCEDUREConvential Ventilation 2
High tidal volume, high inspired oygen fraction (FiO2).
PROCEDUREProtective Ventilation 1
Low tidal volume, PEEP, moderate inspired oygen fraction (FiO2) and recruitment maneuver.
PROCEDUREProtective Ventilation 2
Low tidal volume, PEEP, High inspired oygen fraction (FiO2) and recruitment maneuver.
Sponsors
Xuzhou Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
1.20 Years and older 2.Patients undergoing pulmonary lobectomy
Exclusion criteria
1. Emergency surgery 2. Pulmonary hypertension 3. Forced vital capacity or forced expiratory volume in 1 sec \< 50% of the predicted values 4. Coagulation disorder 5. Pulmonary or extrapulmonary infections 6. History of treatment with steroid in 3 months before surgery 7. History of recurrent pneumothorax 8. History of lung resection surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The proportion of patients with pulmonary complication | up to postoperative 3days | The number of patients with pulmonary complication including atelectasis, pulmonary infiltration, pulmonary edema, pulmonary infection, pleural effusion and pulmonary embolism. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| PaO2 /FiO2 | 10 min after induction, 30 and 60 min after start of one-lung ventilation, 15 min after restart of two-lung ventilation, 1 hour after the end of surgery | — |
| respiratory compliance | 10 min after induction, 30 and 60 min after start of one-lung ventilation, 15 min after restart of two-lung ventilation | Dynamic compliance, Static compliance |
| IL6 | 10 min after induction, 60 min after start of one-lung ventilation, 15 min after restart of two-lung ventilation | — |
| IL10 | 10 min after induction, 60 min after start of one-lung ventilation, 15 min after restart of two-lung ventilation | — |
Countries
China
Contacts
Primary ContactLiu Su Liu, M.D/Ph.D
Outcome results
None listed