Hip Arthroplasty
Conditions
Keywords
intubation, pharyngitis, remifentanil
Brief summary
This investigation is planned to compare the incidence and severity of postoperative sore throat according to the dose of remifentanil.
Interventions
PROCEDUREEndotracheal intubation using laryngoscope
Endotracheal intubation was done using laryngoscope for general anesthesia.
DRUGHigh remifentanil
Remifentanil was started as 0.25 mcg/kg/min. Remifentanil dose was adjusted to maintain blood pressure (20% of preoperative blood pressure) and bispectral index (40-60) by 0.05 mcg/kg/min.
DRUGLow remifentanil
Remifentanil was administered as 0.1 mcg/kg/min.
DRUGHigh sevoflurane
Sevoflurane was started as 0.5 MAC. Sevoflurane dose was adjusted to maintain blood pressure (20% of preoperative blood pressure) and bispectral index (40-60) by 0.2 %.
DRUGLow sevoflurane
Sevoflurane was administered as 0.5 MAC.
Sponsors
Keimyung University Dongsan Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* ASA I-III * Patients scheduled for general anesthesia with endotracheal intubation
Exclusion criteria
* Difficult airway * Rapid sequence induction * Recent sore throat * Recent upper respiratory infection * Asthma * Chronic obstructive pulmonary disease * Chronic cough * Pregnancy * Allergy to remifentanil * Friable teeth * History of head and neck surgery * Multiple intubation attempts * Regional anesthetic agents * Gastric tube * Dexamethasone
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of participants with sore throat | At 24 hr |
Secondary
| Measure | Time frame |
|---|---|
| Number of participants with hoarseness | At 0, 2, 4 and 24 hr |
| Number of participants with cough | At 0, 2, 4 and 24 hr |
| Number of participants with nausea | At 0, 2, 4 and 24 hr |
| Number of participants with vomiting | At 0, 2, 4 and 24 hr |
| Number of participants with sore throat | At 0, 2, 4 and 24 hr |
| Visual analogue scale of postoperative pain | At 0, 2, 4 and 24 hr |
| Number of participants with shivering | At 0, 2, 4 and 24 hr |
| Requirements of analgesics | At 0, 2, 4 and 24 hr |
| Number of participants with additional pain medication | At 0, 2, 4 and 24 hr |
Countries
South Korea
Outcome results
None listed