IVIM, Liver Biopsy, Liver Fibrosis, MRI
Conditions
Keywords
Hepatic fibrosis, IVIM, 1.5T MRI
Brief summary
Quantification of hepatic fibrosis by IVIM sequences in 1.5T MRI.
Detailed description
Early and accurate diagnosis of hepatic fibrosis in patients with chronic liver disease is essential and essential. This assessment could be performed by a non-invasive MRI method. The main objective of this study is to show that the measured perfusion-related scattering value (D \*) is related to the hepatic fibrosis stage. Secondary objectives * Evaluation of infusion fraction (f) and fibrosis stage. * Evaluation of molecular diffusion (D) and fibrosis stage. * Evaluation of ADC and fibrosis stage. * Assess whether there is a link between the etiology of fibrosis and the value of the diffusion.
Interventions
PROCEDUREQuantification of liver fibrosis
Procedure MRI and liver biopsy
Sponsors
University Hospital, Clermont-Ferrand
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Masking description
Open
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Patients undergoing hepatic biopsy (trans-parietal or trans-jugular) in the context of liver disease * Signature of written consent
Exclusion criteria
* Contra-indications to MRI * Refusal of protocol * Underage patients and protected adults
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measured perfusion-related scattering value | at day 1 | The main objective of this study is to show that the measured perfusion-related scattering value (D \*) is related to the hepatic fibrosis stage. |
Secondary
| Measure | Time frame |
|---|---|
| Measured perfusion-related of infusion fraction | at day 1 |
| Measured perfusion-related of molecular diffusion | at day 1 |
| Measured perfusion-related of ADC | at day 1 |
Countries
France
Contacts
Primary ContactPatrick LACARIN
Outcome results
None listed