Liver Cirrhosis, Portal Hypertension
Conditions
Brief summary
Transjugular intrahepatic portosystemic shunt (TIPS) dysfunction is defined as a loss of decompression of the portal venous system due to occlusion or stenosis of the TIPS. Occlusion of the TIPS can either be due to thrombosis or hyperplasia of the intima. Thrombosis of the TIPS usually occurs early and can happen within 24 hours of TIPS creation. The frequency of this complication is on the order of 10%-15% when bare stents are used. Post-TIPS short-term low molecular weight heparin (LMWH) was used to prevent the early thrombosis formation. Weather post-TIPS LMWH was necessary when polytetrafluoroethylene-covered stent was used during TIPS creation was not answered. The present study was designed to evaluate the effect of short-term use of LMWH on early TIPS dysfunction.
Interventions
DRUGlow molecular weight heparin
After TIPS procedure was performed, low molecular weight heparin was given for three days.
Sponsors
West China Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
1. Diagnosis of liver cirrhosis 2. Technical success of TIPS was achieved.
Exclusion criteria
1. Non-cirrhotic portal hypertension 2. Portal vein thrombosis 3. Budd-Chiari syndrome 4. Pregnancy 5. Contradictions to anticoagulation therapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| TIPS patency rate | one year | Analysis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| LMWH-related complication | one month | Analysis |
| Mortality rate | one year | Analysis |
Countries
China
Contacts
Primary Contactxuefeng luo
Outcome results
None listed