Gingival Crevicular Fluid and Placental Tissue Levels of Interleukin-17 as a Possible Marker for Preterm Labor in Patients With Chronic Periodontitis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03171675

Enrollment

Registered

2017-05-31

Start date

2014-12-25

Completion date

2015-06-16

Last updated

2017-07-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Periodontitis, Preterm Labor

Keywords

Chronic Periodontitis, Preterm Labor, Preterm Birth, Interleukin-17, IL-17, Periodontal Disease, Periodontitis, Periodontal risk factors, Medical risk factors

Brief summary

This case control-study measures the levels of Interleukin-17 in gingival crevicular fluid and placental tissue samples of pregnant females as a possible marker in determining whether or not an association exists between chronic periodontitis and preterm labor. Interleukin-17 is a pro-inflammatory cytokine whose levels have been proven to increase in periodontal disease.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

1. Within the age range of 18-35 years 2. Free of any systemic diseases as referenced from Burket's Oral Medicine health history questionnaire (Glick2008) 3. Spontaneous normal term birth at ≥37 weeks of gestation without any obstetrical or medical complications 4. Spontaneous preterm birth (PTB) at \<37 weeks of gestation after uterine contraction or rupture of membranes (Keelan1999)

Exclusion criteria

1. History of medications that may affect the study outcome, such as: current use of systemic corticosteroids or antibiotics for at least one month 2. Genital and urinary tract infections 3. Existing hypertension and diabetes mellitus before pregnancy, autoimmune disease, asthma, and chronic renal disease 4. Multiple pregnancies, cervical cerculage, abnormal placentation, past history of preterm delivery, or antepartum hemorrhage 5. Low or high maternal body mass index

Design outcomes

Primary

Measure	Time frame	Description
Interleukin-17	Single sample from each patient following birth	Interleukin-17 levels in gingival crevicular fluid and placental tissue samples

Outcome results