Impact of Preemptive Intravenous Ibuprofen on Postoperative Edema and Trismus in the Third Molar Teeth

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03170713

Enrollment

Registered

2017-05-31

Start date

2017-05-15

Completion date

2017-11-15

Last updated

2017-05-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Edema, Trismus

Keywords

Preemptive intravenous ibuprofen, trismus, edema, Third molar tooth extraction, Antiinflammatory effect

Brief summary

this study was planned to investigate the antiinflammatory activity of preemptive intravenous ibuprofen on inflammatory complications such as edema and trismus after third molar tooth surgery

Interventions

DRUGarveles

800 mg ibuprofen and 50 mg dexketoprofen in 150 cc normal saline before operation will be given in 30 minutes. The edema size, mouth opening (trismus) will be recorded in all patients in the preoperative period, postoperative period, postoperative 48th hour and 1 st week.

DRUGintrafen

800 mg ibuprofen in 150 cc normal saline before operation will be given in 30 minutes.The edema size, mouth opening (trismus) will be recorded in all patients in the preoperative period, postoperative period, postoperative 48th hour and 1 st week.

OTHERplacebos

150 cc normal saline before operation will be given in 30 minutes.The edema size, mouth opening (trismus) will be recorded in all patients in the preoperative period, postoperative period, postoperative 48th hour and 1 st week.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

20 Years to 35 Years

Healthy volunteers

Inclusion criteria

* Elective 3. Molar tooth extraction * Patients between the ages of 20-35 * Patients who are symptomatic * 3\. Molar tooth angular or horizontal settled patients

Exclusion criteria

* Patients who refuse to participate in the study * Patients under 20 years old, over 35 years old * Patients who are allergic to known non-steroidal anti-inflammatory drugs * Pregnant patients * Patients with severe hepatic insufficiency * Patients with severe renal insufficiency

Design outcomes

Primary

Measure	Time frame	Description
Edema size measured by tape measure method	6 month	the effect of preemptive intravenous ibuprofen on postoperative edema size

Secondary

Measure	Time frame	Description
Maximum mouth opening measured with vernier caliper	6 month	the effect of preemptive intravenous ibuprofen on postoperative trismus rate

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026