Effect of Goal-directed Fluid Therapy on Postoperative Complications

The Effect of Goal-directed Fluid Therapy on Postoperative Complications in Patients Undergoing Laparoscopic Hepatobiliary or Pancreatic Surgery

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03169998

Enrollment

375

Registered

2017-05-30

Start date

2017-01-01

Completion date

2021-12-31

Last updated

2022-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Diseases, Pancreas Disease

Brief summary

* It has been known that the recent application of a goal-directed fluid therapy (GDFT) to the intraoperative fluid infusion in patients contributes to decreasing the prevalence of postoperative complications and shortening the length of study in the intensive care unit as well as hospital stay compared with conventional methods. * Laparoscopic surgery is in a trend that its application is being expanded recently, but there has been no report on the application of GDFT to laparoscopic surgery so far. * To this end, this study aims to apply the intraoperative GDFT protocol in patients undergoing laparoscopic hepatobiliary or pancreatic surgery and to find out whether there is any difference in postoperative recovery and incidences of postoperative complications, by comparing with patients applied with the fluid therapy using existing conventional methods

Interventions

DEVICEEV1000 platform

a continuous arterial pressure monitoring was performed via EV1000/ FloTrac (Edwards Lifesciences, Irvine, CA, USA) (Fig 1) with the continuous monitoring of cardiac index (CI), stroke volume index (SVI) and stroke volume (SV).

Study design

Observational model

CASE_CONTROL

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

* Laparoscopic hepatobiliary or pancreatic surgery

Exclusion criteria

* Patients who do not consent to participation in the study * Pregnant women, breastfeeding women

Design outcomes

Primary

Measure	Time frame
Pulmonary complication	Postoperative 90 day
Wound complication	Postoperative 90 day
Acute kidney injury	Postoperative 90 day
Delirium	Postoperative 90 day
Deep vein thrombosis	Postoperative 90 day
Myocardiac infarction	Postoperative 90 day
Stroke	Postoperative 90 day
Sepsis	Postoperative 90 day
Urinary tract infection	Postoperative 90 day
Death	Postoperative 90 day

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026