Blood Flow Index as an Indicator of Successful Peripheral Nerve Block

Blood Flow Index as an Indicator of Successful Peripheral Nerve Block : A Prospective Observational Study Using Laser Speckle Contrast Imaging.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03169517

Enrollment

110

Registered

2017-05-30

Start date

2017-05-27

Completion date

2017-09-04

Last updated

2017-09-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laser

Keywords

Peripheral nerve block, laser speckle contrast imaging, blood flow index

Brief summary

Laser speckle contrast imaging (LSCI) allows real-time, non-invasive, quantitative measurements of regional blood flow. The aim of this prospective observational study was to evaluate the blood flow changes by LSCI after peripheral nerve block and determine whether this novel optical technique can be used as a reliable indicator of successful blocks.

Detailed description

Methods: One hundred adult patients scheduled for elective upper or lower limb surgery with peripheral nerve block will receive LSCI measurements and pinprick sensory tests before the block and at 5-min intervals till 30 min after the block. The sensitivity, specificity of LSCI as a diagnostic method will be determined by receiver operator characteristic analysis. Clinical Implications: LSCI with quantitative data could be used as an indicator of successful blocks.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Inclusion criteria

* informed consent * American Society of Anesthesiologists physical statusⅠ-Ⅱ * Undergo elective upper or lower limb surgery with peripheral nerve block

Exclusion criteria

* refusal to participate in the study * peripheral vascular disease * digit injury or deficiency * colored or infected fingernails/toenails * BMI\>35 * those who had taken vasodilatory drugs before surgery * preoperative analgesic medications * Any contraindications to peripheral nerve block such as coagulation abnormalities, allergy to local anaesthetics, peripheral neuropathy.

Design outcomes

Primary

Measure	Time frame	Description
diagnostic power of LSCI and pinprick sensory tests for predicting successful and failed blocks	at 5-min intervals till 30 min after regional block	sensitivity and specificity

Secondary

Measure	Time frame	Description
blood flow index	5 min before regional block and at 5-min intervals till 30 min after regional block	perfusion unit(PU)

Countries

China

Outcome results