Myocardial Infarction
Conditions
Keywords
remote ischemic conditioning, beta-blocker
Brief summary
Remote ischemic conditioning has been shown to protect myocardium from ischemia-reperfusion injury during cardiac intervention or cardiac surgery. However, effect of beta-blocker, commonly used cardiovascular medication in patients with cardiac diseases such as hypertension or angina pectoris, on cardioprotective role of remote ischemic conditioning has not been well documented. The purpose of the study is to investigate the effect of beta-blocker on remote ischemic conditioning in healthy volunteers.
Detailed description
This study is prospective cross-over study investigating effect of beta-blocker on cardioprotective role of remote ischemic conditioning. Eleven male healthy volunteers are going to take oral beta-blocker (carvedilol, 12.5 mg once) or not before undergoing remote ischemic conditioning (consisting of 4 cycles of 5-min ischemia and subsequent 5-min reperfusion of upper arm), separated by 6-day wash-out period. To evaluate cardioprotective effect of remote ischemic conditioning, blood samples will be obtained before and after remote ischemic conditioning. Form the samples, human dialysate will be obtained and be perfused to rat heart through Langendorff apparatus before ischemia-reperfusion injury to the rat heart. Changes of infarct size of the rat heart will be compared between the beta-blocker and control groups.
Interventions
DRUGBeta Blockers Carvedilol Phosphate
Subjects are going to take Beta Blockers Carvedilol Phosphate (12.5mg once) before undergoing remote ischemic conditioning.
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
20 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy male volunteer * Not taking any medication
Exclusion criteria
* BMI \< 18 kg/m2 or \> 30 kg/m2 * Allergic history of any medication * Baseline SBP \> 150 mmHg or \< 100 mmHg * Baseline DBP \> 100 mmHg or \< 50 mmHg * Strenuous exercise, excessive caffeine or alcohol, smoking 24 h prior to experiment * Cannot undergoing remote ischemic conditioning for any reason * Refuse to enroll
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in infarct size of rat heart perfused with human dialysate after taking beta-blocker or not to evaluate the effect of beta blocker on remote ischemic conditioning performed to healthy volunteers | 24 hour after remote ischemic conditioning to healthy volunteers | Infarct size measurement after perfusing the rat heart with human serum-derived dialysate and comparison before and after remote ischemic conditioning performed to healthy volunteers |
Countries
South Korea
Outcome results
None listed