Chronic Obstructive Pulmonary Disease, Healthy
Conditions
Keywords
Exercise training, Muscle dysfunction, COPD
Brief summary
The current protocol is developed in the context of a large Research and Innovation (R&I) program aiming the promotion of daily life physical activity in chronic patients registered at clinicaltrials.gov (NCT02976064) and approved by the ethical committee of the Hospital Clinic de Barcelona (HCB/2016/0883). The project is partly supported by the Smart Innovation Strategies promoted by the EU Commission (COMRDI15-1-0016). Specifically, the protocol uses retrospective information collected between 2005-2008 as part of the EU project Biobridge (LSHG-CT-2006-037939). The aims of the current analysis of the retrospective information are 1) to assess training-induced changes in muscle oxygen saturation (StO2) assessed by near-infrared spectroscopy (NIRS) during constant-work rate cycling exercise (CWRE) as a useful marker of the effects of training at limb muscle level in patients with chronic obstructive pulmonary disease (COPD), and 2) to further explore underlying mechanisms of skeletal muscle dysfunction as a characteristic systemic effect of COPD, potentially modifiable with preventive interventions as endurance muscle training. Methods: Incremental exercise (VO2 peak) and CWRE at 70% baseline peak work rate, before and after 8-week of endurance exercise training, were done in healthy sedentary subjects and COPD patients. NIRS was used to assess StO2 in the left vastus internus during the CWRE (before an after training program) (objective 1); and blood samples and muscle biopsies of the quadriceps were obtained at rest (before an after training program) (objective 2).
Interventions
OTHERExercise training
All subjects performed a supervised 8-week, 5 days-week of endurance exercise training program in cycle-ergometer Each session included 5 minutes of warm-up and cool-down pedalling at 30% of peak work-rate (WR) and 50 minutes of interval training. The interval training combined 2 minutes of high-intensity pedalling and 3 minutes of active rest. Work-rate progress during the 8-week period was tailored on individual basis, according to subjects' symptoms, to maximize the training effect. During the first 2 weeks, high intensity pedalling interval was at least 70% of peak WR and active rest interval was at least 40% of peak WR. Thereafter, work-rate was increased by approximately 5% every week up to a maximum of 100% of peak WR during the last 2 weeks for the high intensity period and 50% of peak WR for the active rest. The cycling rate during the sessions was maintained at 60-70 rpm.
Sponsors
Hospital Clinic of Barcelona
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
45 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* COPD diagnosis following GOLD criteria (FEV1/FVC post-broncodilator \<0,7) * Clinical stability for at least 3 months
Exclusion criteria
* Age \<45 years * Any active cancer * Comorbidities which carry high-level of handicap * Other respiratory disease than COPD * No sign of informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Muscle oxygen saturation (StO2) | Baseline - 8 weeks | Near-infrared spectroscopy (NIRS) |
| Skeletal muscle dysfunction | Baseline - 8 weeks | Quadriceps muscle biopsies |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Maximal cardiopulmonary response to exercise training | Baseline - 8 weeks | Incremental exercise test |
| Submaximal cardiopulmonary response to exercise training | Baseline - 8 weeks | Constant work rate exercise test (CWRE) |
| Systemic effects of COPD | Baseline - 8 weeks | Blood sample |
Outcome results
None listed