Blood Coagulation Disorder
Conditions
Brief summary
Fluids administered intravenously may alter whole blood coagulation. However, little is known about the dose-response relationships of hemodilution in plasmalyte-148 solution. Investigators have therefore performed the present study to measure the effect of a plasmalyte-148 solution on the coagulation pathway according to the hemodilution level using a rotational thromboelastometry (ROTEM®) tests.
Interventions
OTHERPlasmalyte-148
Venous blood is taken from 12 healthy volunteers and divided into four specimen bottles, which were diluted with different levels (0%, 20%, 40%, and 60%) using a plasmalyte-148 solution.
Sponsors
Seoul National University Bundang Hospital
Seoul National University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteers * Age: 20 to 65 years * Body weight \> 50 kg * Volunteers who provided informed consent
Exclusion criteria
* Hematologic disease * Anticoagulant medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| FIBTEM | During the rotational thromboelastometry analysis/ an average of 1 hour | Fibrinolytic pathway values of rotational thromboelastometry analysis/ FIBTEM is not an acronym. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| INTEM | During the rotational thromboelastometry analysis/ an average of 1 hour | Intrinsic pathway values of rotational thromboelastometry analysis/ INTEM is not an acronym. |
| EMTEM | During the rotational thromboelastometry analysis/ an average of 1 hour | Extrinsic pathway values of rotational thromboelastometry analysis/ EXTEM is not an acronym. |
Countries
South Korea
Outcome results
None listed