Obesity
Conditions
Keywords
BAT, Bariatric Surgery, Energy Metabolism
Brief summary
The mechanisms of bariatric surgery-induced weight loss go beyond reductions in calorie intake and may involve several other pathways. Recently, brown adipose tissue (BAT) has been added as another potential player. Activation of BAT results in enhanced energy expenditure and promotes weight loss. Here, the investigators will study the effects of bariatric surgery on BAT function by PET/CT studies and molecular analyses of adipose biopsies. The investigators will explore different pathways that may affect BAT activation in this patient population.
Interventions
PROCEDUREBariatric Surgery
Patients will undergo bariatric surgery as routinely scheduled. The type of bariatric procedure will be suggested by the surgeon based on clinical considerations.
Sponsors
Medical University of Vienna
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Age 20 - 50 years * Body mass index (BMI) 35 - 55kg/m2
Exclusion criteria
* Endocrine disease (except hyperlipidemia and substituted hypothyroidism or type 2 diabetes with fasting glucose concentrations \<120mg/dl), kidney disease, inflammatory bowel disease, autoimmune or rheumatologic diseases that require immunosuppressive treatment, active oncologic disease, heart failure. * Medication for any of the above mentioned conditions. * Antibiotic treatment in the past three months * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in BAT activity after bariatric surgery | 4 years | The primary outcome of this study is to determine whether Omega Loop Gastric Bypass and Sleeve Gastrectomy result in increased BAT activity |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Bariatric surgery-induced changes in gut microbiota, bile acid composition and other circulating factors | 4 years | Any pre-versus postsurgical changes of the gut microbiota or bile acid composition or other circulating factors will be evaluated. |
| Association between changes in BAT activity, transcriptional BAT markers and alterations in the gut microbiota profile or bile acid composition | 4 years | Linear regression analyses will be performed to determine any association between BAT activity or molecular signature and changes in the gut microbiota or bile acids |
Countries
Austria
Outcome results
None listed