Osteoarthritis
Conditions
Brief summary
Few data exist to date on the effect of eccentric muscle building in knee osteoarthritis. No studies have compared the effect of eccentric versus concentric reinforcement in knee osteoarthritis. Our study aims to show the effectiveness of an eccentric reinforcement. This is a randomized, interventional trial.
Detailed description
Few data exist to date on the effect of eccentric muscle building in knee osteoarthritis. No studies have compared the effect of eccentric versus concentric reinforcement in knee osteoarthritis. Our study aims to show the effectiveness of an eccentric reinforcement, the interest of a work supervised by a sports coach to maintain activity over time and to study the effect of this activity at the muscular level. The main objective is to study the effect of an eccentric muscle strengthening program on walking performance in osteoarthritis patients. The secondary objectives are to study: the effect of fatigue on walking, the relationship between fatigue and the level of physical activity, the effect of training on perceived fatigue and the effect of training on the function and at muscular level. This is a randomized, interventional trial. 40 subjects are planned. Inclusion criteria include: age 40-85 years, KL 2 and 3. The subjects are divided into two groups to perform either eccentric or concentric work. 2 sessions per week for 6 weeks. At baseline and at the end of the study a clinical evaluation and MRI will be carried out for evaluation of the criteria of judgment
Interventions
OTHEReccentric work
patient will follow 2 eccentric trainings per week during 6 weeks
OTHERconcentric work
patient will follow 2 concentric trainings per week during 6 weeks
Sponsors
Centre Hospitalier Universitaire de Nice
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Autonomous subjects aged 40 to 85 * Subjects meeting ACR criteria for gonarthrosis * Subjects with a score of Kellgren and Lawrence at least one knee greater than or equal to 2 * Signature of consent form * Subjects affiliated to social security
Exclusion criteria
Subject with a Kellgren and Lawrence stadium at 4 for at least one of his two knees * Subjects with symptomatic femoro-patellar arthrosis * Subject with a pathology that makes walking testing impossible. * Non-autonomous subjects, with a pathology impairing walking * Subjects with symptomatic osteoarthritis of the hip and / or with a hip or knee prosthesis * Subject incapable of signing consent and unable to understand information leaflet.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Walking performance | after 6 training weeks | 6-minute walk test |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORChristian H ROUX, PhD
service de Rhumatologie, CHU de NICE
Outcome results
None listed