Osteoarthritis, Knee, Synovitis of Knee
Conditions
Brief summary
To determine whether platelet-rich-plasma (PRP) or HA (hyaluronic acid)injection into synovitis in osteoarthritis(OA) knee can achieve improvement in knee function and reduce synovitis.
Detailed description
Methods: sixty patients with OA knee having unilateral or bilateral synovitis validated by ultrasound (N=40) were studied. All the patients were randomized to receive PRP (N=40) or Hyaluronic acid(HA)(N=40) injection twice at 2-week intervals; Clinical assessments were performed using a visual analog scale(VAS) and The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC index) before injection at baseline, 4 weeks(first evaluation) and 12 weeks(secondary evaluation). Imaging evaluation based on color Doppler ultrasound(CDUS) and the depth of synovial fluid accumulation ,and the width of synovial hypertrophy was performed simultaneously.
Interventions
DRUGplatelet rich plasma
The amount of PPR was about 4-5 cc
DRUGHyaluronic acid
HA was 2.5cc
Sponsors
Taipei Veterans General Hospital, Taiwan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
45 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* diagnosed with OA knee according to ACR guideline 1. stiffness less than 30min 2. cracking sound during activity 3. more than 30min pain for last 2 months 4. non-bed ridden patients 5. no structure abnormality 6. synovitis was proved by US
Exclusion criteria
1\. OA knee secondary to other disease 2 . more than 10 years after diagnosing OA 3. under knee surgery within 3 months 4. autoimmune disease 5. refuses inform/consent process
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC index) | before injection at baseline |
| visual analog scale(VAS) | before injection at baseline |
Secondary
| Measure | Time frame |
|---|---|
| Imaging evaluation based on color Doppler ultrasound(CDUS) and the depth of synovial fluid accumulation ,and the width of synovial hypertrophy was performed simultaneously. | before injection at baseline |
| Imaging evaluation based on color Doppler ultrasound(CDUS) and the depth of synovial fluid accumulation ,and the width of synovial hypertrophy was performed | 4 weeks(first evaluation) |
Countries
Taiwan
Contacts
Primary ContactChien-CHIh Wang, MD
Outcome results
None listed