Appropriate Compatibility of Propofol and Sevoflurane for Orthopaedic Surgery of Patients With MCI

The Appropriate Compatibility of Propofol and Sevoflurane for Orthopaedic Surgery of Patients With Mild Cognitive Impairment

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03165396

Acronym

MCI

Enrollment

100

Registered

2017-05-24

Start date

2016-11-10

Completion date

2018-11-01

Last updated

2018-05-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive Impairment, Mild

Keywords

mild cognitive impairment

Brief summary

According to the inclusion and exclusion criteria, elderly patients undergoing elective orthopedic surgery were randomly divided into four groups. The different combinations of propofol and sevoflurane were used in the four groups: 1 day before surgery, after patients become wide-awake, and 3 days, 7 days, and 3 months after surgery, the patient's cognitive function was evaluated using a professional cognitive scale and other indicators. Finally, statistical analysis.

Interventions

DRUGPropofol

Propofol is the most common clinical anesthetics.

DRUGSevoflurane

Sevoflurane is the most common clinical anesthetics.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

ALL

Age

50 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* Elective orthopaedic surgery * American Society of Anesthesiologists physical status: II

Exclusion criteria

* Neurological diseases that may affect cognitive function (e.g., subdural hematoma) * Hypothyroidism * Alcoholic dementia

Design outcomes

Primary

Measure	Time frame	Description
Evidence of clinically cognitive function decline ：Apolipoprotein J（ApoJ）	Change from Baseline Apolipoprotein J at 7 days	Measurement by ELISA kit

Secondary

Measure	Time frame	Description
Evidence of clinically cognitive function decline ：Soluble CD14（sCD14）	Change from Baseline Soluble CD14 at 7 days	Estimating by ELISA kit
Mini mental Examination(MMSE)	preoperative 24 hours ， 7 days post surgery	A questionnaires is used to assess the cognitive function of patients in clinical.Total range was 0\ 30，≦27 were considered as cognitive function decline
Montreal Cognitive Assessment（MoCA)	preoperative 24 hours ，7 days post surgery	A questionnaires is used to assess the cognitive function of patients in clinical.Total range was 0\ 30，≦27 were considered as cognitive function decline.

Countries

China

Contacts

Primary ContactHaiyun Wang

why@126.com86-13752211206

Backup ContactYimeng Chen

chenyimeng5525@163.com

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026