Breast Cancer
Conditions
Brief summary
The aim of this study is to investigate the effect of addition of different doses of Ketamine locally in acute and chronic post-mastectomy pain after breast cancer surgery and on the probability of developing chronic post-mastectomy pain.
Interventions
DRUGgroup (A)
patients will receive 1mg / kg of Ketamine diluted by 20 ml saline (0.9 % ) and irrigated onto surgical field after hemostats and before skin closure.
DRUGgroup (B)
patients will receive 2 mg /kg of Ketamine diluted by 20 ml saline (0.9 %) and irrigated onto surgical field after hemostasis and before skin closure.
DRUGgroup (c)
patients will receive 3 mg /kg of Ketamine diluted by 20 ml saline (0.9 %) and irrigated onto surgical field after hemostasis and before skin closure.
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
\- American society of heart association class I-II female patients * aged 18-60 years * scheduled for modified radical mastectomy with axillary dissection for breast carcinoma
Exclusion criteria
* known allergy to the study drugs * significant cardiac- * respiratory- * renal or hepatic disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the total amount of morphine consumption | 48 hours | total amount of rescue analgesia |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| pain intensity | 48 hours | pain intensity measured by Visual analogue scale |
Countries
Egypt
Outcome results
None listed