Spine Disease
Conditions
Brief summary
The investigators will do the Goal directed fluid therapy by protocolized fluid management in the experimental group, using PPV to guide the fluid administration, compare with standard fluid management in patients undergoing complex spine surgery.
Interventions
PROCEDUREgoal directed fluid therapy
pulse pressure variation will be used to as a goal to guide fluid administration in this group
OTHERControlled
standard fluid treatment by an anesthesiologist
Sponsors
Mahidol University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* ASA 1-3 * elective surgery * thoracic/lumbar spine surgery \>= 3 levels and duration \>= 3 hours
Exclusion criteria
* Cr \>2 mg/dl or eGFR \< 60 ml/min * coronary artery disease, congestive heart failure or cardiac arrhythmia * BMI \>30 kg/m2 * hemodynamic unstable, preoperatively * uncontrolled hypertension * respiratory system compliance \< 30 ml/cmH2O
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| episode of intraoperative hypotension | intraoperative | Blood pressure will be record continuously using arterial catheter in both group. Number of participants and episode of hypotension (defined as SBP \< 90 mmHg or MAP \< 60 mmHg or decrease of SPB \>= 25% from baseline for 5 minutes or need vasopressor) therapy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| unit of blood transfusion | intraoperative and up to 24 hours postoperatively | all unit of blood transfusion will be record intraoperative and postoperative |
Countries
Thailand
Outcome results
None listed