Effects of Wound Infiltration With Ketamine Versus Dexmedetomidine Added to Bupivacaine on Cytokines

Effects of Local Wound Infiltration With Ketamine Versus Dexmedetomidine Added to Bupivacaine on Inflammatory Cytokines Response After Total Abdominal Hysterectomy

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03164590

Enrollment

Registered

2017-05-23

Start date

2017-06-01

Completion date

2018-09-01

Last updated

2020-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endometrial Adenocarcinoma

Brief summary

This study aims to compare the effects of local wound infiltration with ketamine versus dexmedetomidine when added to bupivacaine on inflammatory cytokine response after total abdominal hysterectomy.

Interventions

DRUGKetamine

patients receive local anesthetic wound infiltration with 1 mg /kg ketamine

DRUGdexmedetomidine

patients receive local anesthetic wound infiltration with 1µg/kg dexmedetomidine

DRUGbupivacaine

patients receive local anesthetic wound infiltration with bupivacaine 0.5 % diluted in 20 ml saline

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

* ASA I-II patients * age range (18-60) years, * weight (50- 90) kg

Exclusion criteria

* allergy to study drugs * significant cardiac disease * respiratory disease * renal disease * hepatic disease

Design outcomes

Primary

Measure	Time frame	Description
severity of pain at rest and on coughing	24 hours	severity of pain at rest and on coughing will be assessed using a 10-cm Visual Analog Scale (0 = no pain and 10 = worst imaginable pain)

Secondary

Measure	Time frame	Description
sedation	24 hours	sedation by using sedation score

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026