Chest Pain, Major Adverse Cardiovascular Events
Conditions
Keywords
endothelial function, chest pain, major adverse cardiovascular events, Endo-PAT
Brief summary
The objective of this study is to determine the prognostic performance of endothelial function assessment, using endothelial peripheral arterial tonometry (Endo-PAT), associated to TIMI risk score, in patients consulting the emergency department for non-traumatic chest pain. To determine the sensitivity, specificity, negative and positive predictive value of this method that was not previously used for this purpose.
Detailed description
Chest pain is a frequent reason for consultation in the emergency room, which can be as much as 5 to 10% of consultants. Stratifying the cardiovascular risk for patients consulting for chest pain is sometimes difficult. The endothelium plays a crucial role in maintaining the tone and vascular integrity and in particular the secretion of vasodilator and vasoconstrictor mediators. In most vascular pathologies, this equilibrium will be broken by the attenuation of the vasodilating function of the endothelium. This is called endothelial dysfunction. Several tools for measuring endothelial function have been developed, the main characteristics of which are: noninvasive, reproducible, independent operators, predictive of the disease, safe for subjects, inexpensive and easy to use. In this study we will be interested in digital plethysmography which has shown its effectiveness in: * Screening for cardiovascular risk in asymptomatic subjects. * The risk of a new cardiovascular event in the sick. * Evaluation of the response to certain therapies. Goal of the study : The objective of this study is to to determine the prognostic performance of endothelial function assessment, using endothelial peripheral arterial tonometry (Endo-PAT), associated to TIMI risk score, in patients consulting the emergency department for non-traumatic chest pain. To determine the sensitivity, specificity, negative and positive predictive value of this method that was not previously used for this purpose, hence the originality of this study.
Interventions
DEVICEDigital plethysmography in stratifying the cardiovascular risk for patients consulting for chest pain
To verify the contribution of digital plethysmography in stratifying the cardiovascular risk for patients consulting for chest pain
Sponsors
University of Monastir
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Intervention model description
Prospective
Eligibility
Sex/Gender
ALL
Age
25 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Any patient ≥ 25 years consulting for chest pain in the emergency department from 8:00 am to 8:00 pm (for the unavailability of the endopat device during the guard).
Exclusion criteria
* Chest pain of traumatic origin. * Hemodynamic instability. * Myocardial infarction requiring urgent revascularization. * Parkinsonism: tremor problem. * Refusal, communication problem.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prognostic performance of Endo-PAT in predincting major adverse cardiovascular events | 30 days | To determine the sensitivity, specificity, negative and positive predictive value of the Endopat associated to TIMI risk score in the the prediction of major adverse cardiovascular events in patients consulting the emergency department for chest pain |
Countries
Tunisia
Outcome results
None listed