Anesthesia, Obstetrical
Conditions
Brief summary
Although the exact mechanism remains unknown, the association of pregnancy and decreased local anesthetic requirement is clear. demonstrated that more local anesthetic is required for cesarean section under combined spinal-epidural anesthesia in preterm compared with term patients.
Detailed description
However, in pregnant patients, venous engorgement is prominent in the supine but not the lateral position, which suggests direct compression of the inferior vena cava by the gravid uterus. Second, an increase in intraabdominal pressure may affect the retroperitoneal area and may cause inward movement of soft tissue in the intervertebral foramina. Recent magnetic resonance imaging studies in pregnant patients, although without intraabdominal pressure measurements, suggested the latter because they showed limited contact of engorged veins along the dural sac which may therefore not be responsible for compression of the dura. If elevated intraabdominal pressure contributes to high anesthetic spread during pregnancy, one would expect a relationship between intraabdominal pressure and maximum sensory block level.
Interventions
DRUGBupivacaine Hydrochloride
intrathecal bupivacaine will be used for spinal anesthesia in obstetric patients undergoing C-section
Sponsors
Assiut University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SCREENING
Masking
NONE
Intervention model description
evaluating relationship of sensory level and other patient factors
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* adult female partner * aged 18 to 40 years. * scheduled for elective cesarean section.
Exclusion criteria
* Patients with coagulopathy or under anti-coagulation therapy. * Gastrointestinal disease, * motion sickness. * diabetes mellitus. * Patients with preeclampsia,
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| sensory level | from allocation until 24 hours post-operative | effect of different parameters in sensory level |
| motor block | from allocation until 24 hours post-operative | effect of different parameters in motor level |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| hypotension | from allocation until 24 hours post-operative | incidence of hypotension after spinal anesthesia |
| vasopressor consumption | from allocation until 24 hours post-operative | total dose of ephedrine consumed by the patients |
Countries
Egypt
Outcome results
None listed