Improved Basophil Activation Test (BAT) in the Diagnostics of Drug Allergy

Improved Basophil Activation Test (BAT) in the Diagnostics of IgE-mediated Drug Allergy

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03164044

Enrollment

Registered

2017-05-23

Start date

2017-01-03

Completion date

2019-06-30

Last updated

2018-12-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Antibiotic Allergy, Drug Allergy, NSAID-Induced Anaphylactoid Reaction

Keywords

Allergy, Drug allergy, Basophil activation test, Flow cytometry

Brief summary

Current study evaluates the use of the improved Basophil Activation Test (BAT) in the diagnostics of IgE-mediated allergy to antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs).

Detailed description

Current study evaluates the use of the improved Basophil Activation Test (BAT) in the diagnostics of IgE-mediated allergy to antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs). Among commonly used CD63/CD203c markers, newly proposed molecules, such as CD69, CD107a, CD164, CD13, CD11b and CD300a will be assayed. Results obtained together with the other clinical data will be used to calculate sensitivity and specificity of the method.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* suspected allergy to antibiotics or NSAIDs in the last 1 year.

Exclusion criteria

* autoimmune diseases; * HIV; * hepatitis B/C; * other acute or chronic infectious diseases; * malignant neoplasms; * leukemia; * other severe acute or chronic intercurrent diseases; * pregnancy/lactation; * refuse of patient to participate in the trial.

Design outcomes

Primary

Measure	Time frame	Description
Sensitivity of the improved Basophil Activation Test (BAT) in the Diagnostics of Drug Allergy	1 month	Sensitivity of the improved Basophil Activation Test (BAT) in the diagnostics of allergy to antibiotics or NSAIDs
Specificity of the improved Basophil Activation Test (BAT) in the Diagnostics of Drug Allergy	1 month	Specificity of the improved Basophil Activation Test (BAT) in the diagnostics of allergy to antibiotics or NSAIDs

Countries

Belarus

Outcome results