The Effects of Dexmedetomidine on cTnI and GP-BB in Patients Undergoing OPCABG

The Effects of Dexmedetomidine on Cardiac Troponin I and Glycogen Phosphorylase Isoenzyme BB in Patients Undergoing Off-pump Coronary Artery Bypass Grafting

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03163693

Enrollment

Registered

2017-05-23

Start date

2016-02-29

Completion date

2017-05-31

Last updated

2017-05-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Bypass, Off-Pump

Keywords

Dexmedetomidine, Cardiac Troponin I, Glycogen Phosphorylase Isoenzyme BB

Brief summary

The purpose of this study is to observe the impact of dexmedetomidine on Cardiac Troponin I and Glycogen Phosphorylase Isoenzyme BB in patients undergoing off-pump coronary artery bypass Grafting.

Detailed description

Dexmedetomidine is a highly selective α2-adrenoceptor agonist used as a sedative or adjuvant anesthetic drug in clinical settings.From clinical observation, dexmedetomidine has been revealed to reduce the incidence of cardiovascular adverse events in patients with heart diseases during non-cardiac surgeries.Therefore, the aim of this sudy is to observe the impact of dexmedetomidine on Cardiac Troponin I and Glycogen Phosphorylase Isoenzyme BB in patients during cardiac surgeries.

Interventions

DRUGdexmedetomidine

receive dexmedetomidine 0.5 μg/kg

OTHERnormal saline

receive equal volume of normal saline

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

40 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Patients undergoing off - pump coronary artery bypass grafting * ASA physical status III-IV * Aged 40-70 years * NYHA physical status II-III

Exclusion criteria

* Bradycardia * Atrioventricular block * Echocardiography suggested:LVEF \<40%, LVED\>65mm * Allergic to the drugs

Design outcomes

Primary

Measure	Time frame	Description
Change of cardiac troponin I at preoperative, postoperative，and 24 hours after surgery.	At preoperative, postoperative，and 24 hours after surgery.	Blood samples were sampled at preoperative, postoperative，and 24 hours after surgery for the cTnI，which were analyzed by using enzyme linked immunosorbent assay (ELISA).
Change of Glycogen Phosphorylase Isoenzyme BB at preoperative, postoperative，and 24 hours after surgery.	At preoperative, postoperative，and 24 hours after surgery.	Blood samples were sampled at preoperative, postoperative，and 24 hours after surgery for the GP-BB，which were analyzed by using enzyme linked immunosorbent assay (ELISA).

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026