Hyperkalemia, Mannitol Adverse Reaction
Conditions
Brief summary
This is an observational study designed to research the effect of mannitol on the concentration of intraoperative serum potassium in patients undergoing craniotomy, and to guide the safe use of mannitol during craniotomy.
Detailed description
Patients were assigned to receive 20% mannitol (1g/kg) solution administered intravenously 15-20 minutes at the time of drilling skull.The serum potassium was measured by arterial blood gas analysis before infusion (T0), infusion finished (T1), 15min (T2), 30min (T3), 60min (T4) and 120min (T5) after infusion.
Interventions
OTHERMannitol
Mannitol was intravenous infused within 15-20 mins when drilling skull
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* age 18 to 70 * American Society of Anesthesiologists physical status I to II * liver and kidney function is normal * preoperative concentration of serum potassium was from 3.5 to 5.5 mmol/L
Exclusion criteria
* history or presence of congestive heart failure (New York Heart Association class III to IV) * history or presence of renal failure(diabetes insipidus, or syndrome of inappropriate antidiuretic hormone secretion) * intraoperative blood transfusion
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the concentration of serum potassium | two hours within infusioning mannitol | measured by arterial blood gas analysis |
Countries
China
Outcome results
None listed