Knee Osteoarthritis
Conditions
Brief summary
The aim of this study was to assess a novel approach to treating severe knee osteoarthritis by targeting synovialmembrane, superficial articular cartilage, synovial fluid, and subchondral bone by combining intra-articular injections and intraosseous infiltrations of platelet rich plasma.This study explored a new strategy consisting of intraosseous infiltrations of platelet rich plasma into the subchondral bone in combination with the conventional intra-articular injection in order to tackle several knee joint tissues simultaneously.
Interventions
BIOLOGICALPlatelet Rich Plasma
Combination of Intraosseous and Intraarticular Infiltration of Platelet Rich Plasma
Sponsors
Unidad de Cirugía Artroscópica
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 77 Years
Healthy volunteers
No
Inclusion criteria
* Patients of both sexes aged 40 to 77 years. * Predominant internal tibiofemoral knee osteoarthritis. * Joint pain above 2.5 VAS points. * Radiographic severity degrees 3 and 4 according to Ahlbäck scale. * Values of body mass index between 20 and 33. * Possibility for observation during the follow-up period.
Exclusion criteria
* Bilateral knee osteoarthritis which requires infiltration in both knees. * Values of body mass index \> 33. * Polyarticular disease diagnosed. * Severe mechanical deformity (diaphyseal varus of 4∘ and valgus of 16∘). * Arthroscopy in the last year prior to treatment. * Intra-articular infiltration of hyaluronic acid in the past 6 months. * Systemic autoimmune rheumatic disease (connective tissue diseases and systemic necrotizing vasculitis). * Poorly controlled diabetes mellitus (glycosylated hemoglobin above 9%). * Blood disorders (thrombopathy, thrombocytopenia, and anemia with Hb \< 9). * Undergoing immunosuppressive therapy and/or warfarin. * Treatment with corticosteroids during the 6 months prior to inclusion in the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain according to KOOS scale at 6 months after treatment | 6 months | Pain according to KOOS scale |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Symptoms according to KOOS scale at 6 months after treatment | 6 months | According to KOOS scale |
| Function according to KOOS scale at 6 months after treatment | 6 months | According to KOOS scale |
| Sport Activity according to KOOS scale at 6 months after treatment | 6 months | According to KOOS scale |
| QoL according to KOOS scale at 6 months after treatment | 6 months | According to KOOS scale |
Outcome results
None listed